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Delayed Cellular Maturation and Decreased Immunoglobulin κ Light Chain Production In Immature B Lymphocytes Lacking B Cell Linker Protein
B cell linker (BLNK) protein is a component of the B cell receptor (BCR) signaling pathway and BLNK(−/−) mice have a block in B lymphopoiesis at the pro-B/pre-B cell stage. To study the effect of BLNK mutation at later stages of B cell development, we introduce an innocuous transgenic BCR into BLNK(...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193924/ https://www.ncbi.nlm.nih.gov/pubmed/12119344 http://dx.doi.org/10.1084/jem.20020172 |