H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation

Changes in chromatin structure induced by posttranslational modifications of histones are important regulators of genomic function. Phosphorylation of histone H2AX promotes DNA repair and helps maintain genomic stability. Although B cells lacking H2AX show impaired class switch recombination (CSR),...

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Detalles Bibliográficos
Autores principales: Reina-San-Martin, Bernardo, Difilippantonio, Simone, Hanitsch, Leif, Masilamani, Revati F., Nussenzweig, André, Nussenzweig, Michel C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193951/
https://www.ncbi.nlm.nih.gov/pubmed/12810694
http://dx.doi.org/10.1084/jem.20030569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193951/
https://www.ncbi.nlm.nih.gov/pubmed/12810694
http://dx.doi.org/10.1084/jem.20030569

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