Cargando…

H2AX Is Required for Recombination Between Immunoglobulin Switch Regions but Not for Intra-Switch Region Recombination or Somatic Hypermutation

Changes in chromatin structure induced by posttranslational modifications of histones are important regulators of genomic function. Phosphorylation of histone H2AX promotes DNA repair and helps maintain genomic stability. Although B cells lacking H2AX show impaired class switch recombination (CSR),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reina-San-Martin, Bernardo, Difilippantonio, Simone, Hanitsch, Leif, Masilamani, Revati F., Nussenzweig, André, Nussenzweig, Michel C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193951/ https://www.ncbi.nlm.nih.gov/pubmed/12810694 http://dx.doi.org/10.1084/jem.20030569

Ejemplares similares

ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
por: Reina-San-Martin, Bernardo, et al.
Publicado: (2004)

AID function in somatic hypermutation and class switch recombination: AID function in somatic hypermutation and class switch recombination
por: Yu, Kefei
Publicado: (2022)

Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region
por: Dunnick, Wesley A., et al.
Publicado: (2009)

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
por: Pan-Hammarström, Qiang, et al.
Publicado: (2006)

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination
por: Jeevan-Raj, Beena Patricia, et al.
Publicado: (2011)

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation
por: Nagaoka, Hitoshi, et al.
Publicado: (2002)

53BP1 is required for class switch recombination
por: Ward, Irene M., et al.
Publicado: (2004)

Regulation of class switch recombination and somatic mutation by AID phosphorylation
por: McBride, Kevin M., et al.
Publicado: (2008)

Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching
por: Bothmer, Anne, et al.
Publicado: (2013)

The cohesin complex regulates immunoglobulin class switch recombination
por: Thomas-Claudepierre, Anne-Sophie, et al.
Publicado: (2013)

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
por: Martomo, Stella A., et al.
Publicado: (2004)

The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination
por: Krijger, Peter H. L., et al.
Publicado: (2010)

DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination
por: Faili, Ahmad, et al.
Publicado: (2004)

The role of G-density in switch region repeats for immunoglobulin class switch recombination
por: Zhang, Zheng Z., et al.
Publicado: (2014)

Parp3 Negatively Regulates Immunoglobulin Class Switch Recombination
por: Robert, Isabelle, et al.
Publicado: (2015)

Ikaros controls isotype selection during immunoglobulin class switch recombination
por: Sellars, MacLean, et al.
Publicado: (2009)

Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
por: Martin, Alberto, et al.
Publicado: (2003)

Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination
por: He, Yafeng, et al.
Publicado: (2020)

Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation
por: Maizels, Nancy
Publicado: (2000)

Immunoglobulin class-switch recombination deficiencies
por: Durandy, Anne, et al.
Publicado: (2012)

Quantitative Regulation of Class Switch Recombination by Switch Region Transcription
por: Lee, Chung-Gi, et al.
Publicado: (2001)

HoxC4 binds to the Aicda promoter to induce AID expression, class switch DNA recombination and somatic hypermutation
por: Park, Seok-Rae, et al.
Publicado: (2009)

Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
por: Nguyen, Thuy Vy, et al.
Publicado: (2014)

AID from bony fish catalyzes class switch recombination
por: Barreto, Vasco M., et al.
Publicado: (2005)

DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
por: Wu, Xiaoming, et al.
Publicado: (2007)

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
por: Bothmer, Anne, et al.
Publicado: (2010)

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation
por: Spanjaard, Aldo, et al.
Publicado: (2023)

The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination
por: Delgado-Benito, Verónica, et al.
Publicado: (2018)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2010)

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4
por: Boboila, Cristian, et al.
Publicado: (2013)

Somatic Hypermutation Shapes the Antibody Repertoire of Memory B Cells in Humans
por: Meffre, Eric, et al.
Publicado: (2001)

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
por: Rouaud, Pauline, et al.
Publicado: (2013)

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination
por: Robert, Isabelle, et al.
Publicado: (2009)

Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide
Publicado: (1992)

The μ Switch Region Tandem Repeats Are Important, but Not Required, for Antibody Class Switch Recombination
por: Luby, Thomas M., et al.
Publicado: (2001)

An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex
por: Kracker, Sven, et al.
Publicado: (2015)

Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice
por: Lumsden, Joanne M., et al.
Publicado: (2004)

Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase
por: McBride, Kevin M., et al.
Publicado: (2004)

Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation
por: Spence, Janice M, et al.
Publicado: (2015)

Somatic hypermutation of an immunoglobulin mu heavy chain transgene
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_csmfk8fj0ui8299ok6cd4ekisf