Cargando…

Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase

Experiments in nonobese diabetic (NOD) mice that lacked expression of glutamic acid decarboxylase (GAD) in β cells have suggested that GAD represents an autoantigen essential for initiating and maintaining the diabetogenic immune response. Several attempts of inducing GAD-specific recessive toleranc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaeckel, Elmar, Klein, Ludger, Martin-Orozco, Natalia, von Boehmer, Harald
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193961/ https://www.ncbi.nlm.nih.gov/pubmed/12796471 http://dx.doi.org/10.1084/jem.20030215

Ejemplares similares

Transgenically Induced GAD Tolerance Curtails the Development of Early β-Cell Autoreactivities but Causes the Subsequent Development of Supernormal Autoreactivities to Other β-Cell Antigens
por: Tian, Jide, et al.
Publicado: (2009)

Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice
por: Alkan, Manal, et al.
Publicado: (2015)

Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus
por: Pedotti, Rosetta, et al.
Publicado: (2003)

Neurological Disorders Associated with Glutamic Acid Decarboxylase Antibodies
por: Herard, Kimberly, et al.
Publicado: (2019)

Oral tolerance: is it all retinoic acid?
por: von Boehmer, Harald
Publicado: (2007)

Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice
por: Miyata, Shigeo, et al.
Publicado: (2021)

Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice
por: Funda, David P., et al.
Publicado: (2018)

Three Distinct Glutamate Decarboxylase Genes in Vertebrates
por: Grone, Brian P., et al.
Publicado: (2016)

Molecular Analysis of Glutamate Decarboxylases in Enterococcus avium
por: Gu, Xinyi, et al.
Publicado: (2021)

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes
Publicado: (1995)

Anti-glutamic acid decarboxylase antibody positive neurological syndromes
por: Tohid, Hassaan
Publicado: (2016)

Neurological Manifestations of Glutamic Acid Decarboxylase Autoimmunity in Indian Patients
por: Thevarkalam, Meena, et al.
Publicado: (2023)

Limbic encephalitis with antibodies to glutamic acid decarboxylase presenting with brainstem symptoms
por: Incecik, Faruk, et al.
Publicado: (2015)

Increased glutamic acid decarboxylase expression in the hypothalamic suprachiasmatic nucleus in depression
por: Wu, Xueyan, et al.
Publicado: (2017)

Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies
por: Falip, Mercè, et al.
Publicado: (2019)

Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias
por: Mitoma, Hiroshi, et al.
Publicado: (2017)

Parallel Strategy Increases the Thermostability and Activity of Glutamate Decarboxylase
por: Zhang, Qing-Fei, et al.
Publicado: (2020)

Immunological Tolerance
por: von Boehmer, Harald, et al.
Publicado: (2010)

Divergent Evolution of the Activity and Regulation of the Glutamate Decarboxylase Systems in Listeria monocytogenes EGD-e and 10403S: Roles in Virulence and Acid Tolerance
por: Feehily, Conor, et al.
Publicado: (2014)

Hypercapnic ventilatory response in mice lacking the 65 kDa isoform of Glutamic Acid Decarboxylase (GAD65)
por: Bissonnette, John M, et al.
Publicado: (2004)

Contribution of glutamate decarboxylase in Lactobacillus reuteri to acid resistance and persistence in sourdough fermentation
por: Su, Marcia S, et al.
Publicado: (2011)

Glutamic acid decarboxylase antibodies in neurocritical patients: a culprit or a bystander?
por: Wang, Dongmei, et al.
Publicado: (2020)

Epilepsy in patients with insulin-dependent diabetes and relation to glutamic acid decarboxylase 65
por: Mahmoud, Adel A., et al.
Publicado: (2020)

The clinical relevance of anti-glutamic acid decarboxylase antibodies in children with encephalitis/encephalopathy
por: Hou, Ju-Yin, et al.
Publicado: (2023)

Effects of 4-methylimidazole on cerebral glutamate decarboxylase activity and specific GABA receptor binding in mice
por: Sivertsen, Tore, et al.
Publicado: (2009)

Effects of Jobelyn(®) on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice
por: Asehinde, Stephen, et al.
Publicado: (2018)

Calmodulin-dependent and calmodulin-independent glutamate decarboxylases in apple fruit
por: Trobacher, Christopher P, et al.
Publicado: (2013)

Biochemical and spectroscopic properties of Brucella microti glutamate decarboxylase, a key component of the glutamate-dependent acid resistance system
por: Grassini, Gaia, et al.
Publicado: (2015)

Glutamic acid decarboxylase 67 haplodeficiency in mice: consequences of postweaning social isolation on behavior and changes in brain neurochemical systems
por: Nullmeier, Sven, et al.
Publicado: (2020)

Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin- dependent diabetes
Publicado: (1993)

Role of the Proteasome in Excitotoxicity-Induced Cleavage of Glutamic Acid Decarboxylase in Cultured Hippocampal Neurons
por: Baptista, Márcio S., et al.
Publicado: (2010)

Calpain Cleavage of Brain Glutamic Acid Decarboxylase 65 Is Pathological and Impairs GABA Neurotransmission
por: Buddhala, Chandana, et al.
Publicado: (2012)

Cognitive decline in a patient with anti-glutamic acid decarboxylase autoimmunity; case report
por: Takagi, Masahito, et al.
Publicado: (2011)

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
por: Langendorf, Christopher G., et al.
Publicado: (2013)

Clinical heterogeneity of adult Japanese diabetes depending on titers of glutamic acid decarboxylase autoantibodies
por: Aoyama, Tomohisa, et al.
Publicado: (2012)

Antibodies to Inhibitory Synaptic Proteins in Neurological Syndromes Associated with Glutamic Acid Decarboxylase Autoimmunity
por: Gresa-Arribas, Nuria, et al.
Publicado: (2015)

A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
por: Pancotto, Theresa E., et al.
Publicado: (2017)

Glutamate Decarboxylase from Lactic Acid Bacteria—A Key Enzyme in GABA Synthesis
por: Yogeswara, Ida Bagus Agung, et al.
Publicado: (2020)

Molecular evolution and population genetics of glutamate decarboxylase acid resistance pathway in lactic acid bacteria
por: Sezgin, Efe, et al.
Publicado: (2023)

Identification and molecular cloning of glutamate decarboxylase gene from Lactobacillus casei
por: Tavakoli, Yasaman, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vnjenmdi336fodqg53rlgvvjcv