Regulation of Fyn Through Translocation of Activated Lck into Lipid Rafts

Whether or how the activation of Lck and Fyn during T cell receptor (TCR) signaling is coordinated, and their delivery of function integrated, is unknown. Here we show that lipid rafts function to segregate Lck and Fyn in T cells before activation. Coaggregation of TCR and CD4 leads to Lck activatio...

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Detalles Bibliográficos
Autores principales: Filipp, Dominik, Zhang, Jenny, Leung, Bernadine L., Shaw, Andrey, Levin, Steven D., Veillette, André, Julius, Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193969/
https://www.ncbi.nlm.nih.gov/pubmed/12732664
http://dx.doi.org/10.1084/jem.20022112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193969/
https://www.ncbi.nlm.nih.gov/pubmed/12732664
http://dx.doi.org/10.1084/jem.20022112

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