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Raf-1 Antagonizes Erythroid Differentiation by Restraining Caspase Activation
The Raf kinases are key signal transducers activated by mitogens or oncogenes. The best studied Raf isoform, Raf-1, was identified as an inhibitor of apoptosis by conventional and conditional gene ablation in mice. c-raf-1 (−) (/) (−) embryos are growth retarded and anemic, and die at midgestation w...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193984/ https://www.ncbi.nlm.nih.gov/pubmed/12438425 http://dx.doi.org/10.1084/jem.20020562 |