Constitutive Activation of the Src Family Kinase Hck Results in Spontaneous Pulmonary Inflammation and an Enhanced Innate Immune Response

To identify the physiological role of Hck, a functionally redundant member of the Src family of tyrosine kinases expressed in myelomonocytic cells, we generated Hck(F/F) “knock-in” mice which carry a targeted tyrosine (Y) to phenylalanine (F) substitution of the COOH-terminal, negative regulatory Y(...

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Detalles Bibliográficos
Autores principales: Ernst, Matthias, Inglese, Melissa, Scholz, Glen M., Harder, Kenneth W., Clay, Fiona J., Bozinovski, Steven, Waring, Paul, Darwiche, Rima, Kay, Tom, Sly, Peter, Collins, Rachel, Turner, Debra, Hibbs, Margaret L., Anderson, Gary P., Dunn, Ashley R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193996/
https://www.ncbi.nlm.nih.gov/pubmed/12208875
http://dx.doi.org/10.1084/jem.20020873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193996/
https://www.ncbi.nlm.nih.gov/pubmed/12208875
http://dx.doi.org/10.1084/jem.20020873

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