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Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells
Genetic studies have revealed that Cbl-b plays a negative role in the antigen receptor–mediated proliferation of lymphocytes. However, we show that Cbl-b–deficient DT40 B cells display reduced phospholipase C (PLC)-γ2 activation and Ca(2+) mobilization upon B cell receptor (BCR) stimulation. In addi...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194016/ https://www.ncbi.nlm.nih.gov/pubmed/12093870 http://dx.doi.org/10.1084/jem.20020068 |