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The Proliferative Capacity of Individual Naive CD4(+)T Cells Is Amplified by Prolonged T Cell Antigen Receptor Triggering
Strong antigenic encounter by T cells rapidly induces immunological synapse formation and surface T cell receptor (TCR) downregulation. Although surface TCR expression can remain low for several days, T cells can still sustain antigenic signaling. It has been unclear whether prolonged antigenic sign...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194051/ https://www.ncbi.nlm.nih.gov/pubmed/12235212 http://dx.doi.org/10.1084/jem.20020158 |