A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins, respond poorly to immunization with type II thymus-independent antigen, and are defective in their primary and secondary responses...

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Autores principales: Clayton, Elizabeth, Bardi, Giuseppe, Bell, Sarah E., Chantry, David, Downes, C. Peter, Gray, Alexander, Humphries, Lisa A., Rawlings, David, Reynolds, Helen, Vigorito, Elena, Turner, Martin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194055/
https://www.ncbi.nlm.nih.gov/pubmed/12235209
http://dx.doi.org/10.1084/jem.20020805
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author Clayton, Elizabeth
Bardi, Giuseppe
Bell, Sarah E.
Chantry, David
Downes, C. Peter
Gray, Alexander
Humphries, Lisa A.
Rawlings, David
Reynolds, Helen
Vigorito, Elena
Turner, Martin
author_facet Clayton, Elizabeth
Bardi, Giuseppe
Bell, Sarah E.
Chantry, David
Downes, C. Peter
Gray, Alexander
Humphries, Lisa A.
Rawlings, David
Reynolds, Helen
Vigorito, Elena
Turner, Martin
author_sort Clayton, Elizabeth
collection PubMed
description Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins, respond poorly to immunization with type II thymus-independent antigen, and are defective in their primary and secondary responses to thymus-dependent antigen. p110δ(−/−) B cells proliferate poorly in response to B cell receptor (BCR) or CD40 signals in vitro, fail to activate protein kinase B, and are prone to apoptosis. p110δ function is required for BCR-mediated calcium flux, activation of phosphlipaseCγ2, and Bruton's tyrosine kinase. Thus, p110δ plays a critical role in B cell homeostasis and function.
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spelling pubmed-21940552008-04-11 A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation Clayton, Elizabeth Bardi, Giuseppe Bell, Sarah E. Chantry, David Downes, C. Peter Gray, Alexander Humphries, Lisa A. Rawlings, David Reynolds, Helen Vigorito, Elena Turner, Martin J Exp Med Article Mice lacking the p110δ catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins, respond poorly to immunization with type II thymus-independent antigen, and are defective in their primary and secondary responses to thymus-dependent antigen. p110δ(−/−) B cells proliferate poorly in response to B cell receptor (BCR) or CD40 signals in vitro, fail to activate protein kinase B, and are prone to apoptosis. p110δ function is required for BCR-mediated calcium flux, activation of phosphlipaseCγ2, and Bruton's tyrosine kinase. Thus, p110δ plays a critical role in B cell homeostasis and function. The Rockefeller University Press 2002-09-16 /pmc/articles/PMC2194055/ /pubmed/12235209 http://dx.doi.org/10.1084/jem.20020805 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Clayton, Elizabeth
Bardi, Giuseppe
Bell, Sarah E.
Chantry, David
Downes, C. Peter
Gray, Alexander
Humphries, Lisa A.
Rawlings, David
Reynolds, Helen
Vigorito, Elena
Turner, Martin
A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
title A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
title_full A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
title_fullStr A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
title_full_unstemmed A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
title_short A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
title_sort crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in b cell development and activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194055/
https://www.ncbi.nlm.nih.gov/pubmed/12235209
http://dx.doi.org/10.1084/jem.20020805
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