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Mutation in Fas Ligand Impairs Maturation of Thymocytes Bearing Moderate Affinity T Cell Receptors
Fas ligand, best known as a death-inducer, is also a costimulatory molecule required for maximal proliferation of mature antigen-specific CD4(+) and CD8(+) T cells. We now extend the role of Fas ligand by showing that it can also influence thymocyte development. T cell maturation in some, but not al...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194074/ https://www.ncbi.nlm.nih.gov/pubmed/12860933 http://dx.doi.org/10.1084/jem.20030220 |