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Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

Type 1 diabetes and other organ-specific autoimmune diseases often cluster together in human families and in congenic strains of NOD (nonobese diabetic) mice, but the inherited immunoregulatory defects responsible for these diseases are unknown. Here we track the fate of high avidity CD4 T cells rec...

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Detalles Bibliográficos
Autores principales: Lesage, Sylvie, Hartley, Suzanne B., Akkaraju, Srinivas, Wilson, Judith, Townsend, Michelle, Goodnow, Christopher C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194101/
https://www.ncbi.nlm.nih.gov/pubmed/12417628
http://dx.doi.org/10.1084/jem.20020735