AML1-ETO Inhibits Maturation of Multiple Lymphohematopoietic Lineages and Induces Myeloblast Transformation in Synergy with ICSBP Deficiency

The translocation (8;21), generating the AML1-ETO fusion protein, is one of the most frequent chromosomal abnormalities associated with acute myelogenous leukemia (AML). To elucidate its role in oncogenesis, bone marrow (BM) cells were infected with a retroviral vector carrying AML1-ETO and transpla...

Descripción completa

Detalles Bibliográficos
Autores principales: Schwieger, Maike, Löhler, Jürgen, Friel, Jutta, Scheller, Marina, Horak, Ivan, Stocking, Carol
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194108/
https://www.ncbi.nlm.nih.gov/pubmed/12417632
http://dx.doi.org/10.1084/jem.20020824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194108/
https://www.ncbi.nlm.nih.gov/pubmed/12417632
http://dx.doi.org/10.1084/jem.20020824

Ejemplares similares