Use of a Small Molecule CCR5 Inhibitor in Macaques to Treat Simian Immunodeficiency Virus Infection or Prevent Simian–Human Immunodeficiency Virus Infection

Human immunodeficiency virus type 1 (HIV-1) fuses with cells after sequential interactions between its envelope glycoproteins, CD4 and a coreceptor, usually CC chemokine receptor 5 (CCR5) or CXC receptor 4 (CXCR4). CMPD 167 is a CCR5-specific small molecule with potent antiviral activity in vitro. W...

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Detalles Bibliográficos
Autores principales: Veazey, Ronald S., Klasse, Per Johan, Ketas, Thomas J., Reeves, Jacqueline D., Piatak, Michael, Kunstman, Kevin, Kuhmann, Shawn E., Marx, Preston A., Lifson, Jeffrey D., Dufour, Jason, Mefford, Megan, Pandrea, Ivona, Wolinsky, Steven M., Doms, Robert W., DeMartino, Julie A., Siciliano, Salvatore J., Lyons, Kathy, Springer, Martin S., Moore, John P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194125/
https://www.ncbi.nlm.nih.gov/pubmed/14623909
http://dx.doi.org/10.1084/jem.20031266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194125/
https://www.ncbi.nlm.nih.gov/pubmed/14623909
http://dx.doi.org/10.1084/jem.20031266

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