Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

The Vav family of Rho guanine nucleotide exchange factors is thought to orchestrate signaling events downstream of lymphocyte antigen receptors. Elucidation of Vav function has been obscured thus far by the expression of three highly related family members. We generated mice lacking all Vav family p...

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Detalles Bibliográficos
Autores principales: Fujikawa, Keiko, Miletic, Ana V., Alt, Frederick W., Faccio, Roberta, Brown, Tracie, Hoog, Jeremy, Fredericks, Jessica, Nishi, Shinzo, Mildiner, Shirly, Moores, Sheri L., Brugge, Joan, Rosen, Fred S., Swat, Wojciech
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194126/
https://www.ncbi.nlm.nih.gov/pubmed/14623913
http://dx.doi.org/10.1084/jem.20030874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194126/
https://www.ncbi.nlm.nih.gov/pubmed/14623913
http://dx.doi.org/10.1084/jem.20030874

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