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Conversion of Peripheral CD4(+)CD25(−) Naive T Cells to CD4(+)CD25(+) Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
CD4(+)CD25(+) regulatory T cells (T(reg)) are instrumental in the maintenance of immunological tolerance. One critical question is whether T(reg) can only be generated in the thymus or can differentiate from peripheral CD4(+)CD25(−) naive T cells. In this paper, we present novel evidence that conver...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194145/ https://www.ncbi.nlm.nih.gov/pubmed/14676299 http://dx.doi.org/10.1084/jem.20030152 |