Structure of the Human Protein Kinase MPSK1 Reveals an Atypical Activation Loop Architecture

The activation segment of protein kinases is structurally highly conserved and central to regulation of kinase activation. Here we report an atypical activation segment architecture in human MPSK1 comprising a β sheet and a large α-helical insertion. Sequence comparisons suggested that similar activ...

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Detalles Bibliográficos
Autores principales: Eswaran, Jeyanthy, Bernad, Antonio, Ligos, Jose M., Guinea, Barbara, Debreczeni, Judit É., Sobott, Frank, Parker, Sirlester A., Najmanovich, Rafael, Turk, Benjamin E., Knapp, Stefan
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194165/
https://www.ncbi.nlm.nih.gov/pubmed/18184589
http://dx.doi.org/10.1016/j.str.2007.10.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194165/
https://www.ncbi.nlm.nih.gov/pubmed/18184589
http://dx.doi.org/10.1016/j.str.2007.10.026

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