129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

Recent studies suggest that DNA polymerase η (polη) and DNA polymerase ι (polι) are involved in somatic hypermutation of immunoglobulin variable genes. To test the role of polι in generating mutations in an animal model, we first characterized the biochemical properties of murine polι. Like its huma...

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Detalles Bibliográficos
Autores principales: McDonald, John P., Frank, Ekaterina G., Plosky, Brian S., Rogozin, Igor B., Masutani, Chikahide, Hanaoka, Fumio, Woodgate, Roger, Gearhart, Patricia J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194173/
https://www.ncbi.nlm.nih.gov/pubmed/12925679
http://dx.doi.org/10.1084/jem.20030767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194173/
https://www.ncbi.nlm.nih.gov/pubmed/12925679
http://dx.doi.org/10.1084/jem.20030767

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