Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections

We identified previously a patient with recurrent bacterial infections who failed to respond to gram-negative LPS in vivo, and whose leukocytes were profoundly hyporesponsive to LPS and IL-1 in vitro. We now demonstrate that this patient also exhibits deficient responses in a skin blister model of a...

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Detalles Bibliográficos
Autores principales: Medvedev, Andrei E., Lentschat, Arnd, Kuhns, Douglas B., Blanco, Jorge C.G., Salkowski, Cindy, Zhang, Shuling, Arditi, Moshe, Gallin, John I., Vogel, Stefanie N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194174/
https://www.ncbi.nlm.nih.gov/pubmed/12925671
http://dx.doi.org/10.1084/jem.20030701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194174/
https://www.ncbi.nlm.nih.gov/pubmed/12925671
http://dx.doi.org/10.1084/jem.20030701

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