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Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections
We identified previously a patient with recurrent bacterial infections who failed to respond to gram-negative LPS in vivo, and whose leukocytes were profoundly hyporesponsive to LPS and IL-1 in vitro. We now demonstrate that this patient also exhibits deficient responses in a skin blister model of a...
Autores principales: | Medvedev, Andrei E., Lentschat, Arnd, Kuhns, Douglas B., Blanco, Jorge C.G., Salkowski, Cindy, Zhang, Shuling, Arditi, Moshe, Gallin, John I., Vogel, Stefanie N. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194174/ https://www.ncbi.nlm.nih.gov/pubmed/12925671 http://dx.doi.org/10.1084/jem.20030701 |
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