Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8(+) T Cells

Many tumor-associated antigens are derived from nonmutated “self” proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo with vaccination. These T cells exist in a functionally tolerant state, as they rarely result in tumor eradicat...

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Detalles Bibliográficos
Autores principales: Overwijk, Willem W., Theoret, Marc R., Finkelstein, Steven E., Surman, Deborah R., de Jong, Laurina A., Vyth-Dreese, Florry A., Dellemijn, Trees A., Antony, Paul A., Spiess, Paul J., Palmer, Douglas C., Heimann, David M., Klebanoff, Christopher A., Yu, Zhiya, Hwang, Leroy N., Feigenbaum, Lionel, Kruisbeek, Ada M., Rosenberg, Steven A., Restifo, Nicholas P.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194177/
https://www.ncbi.nlm.nih.gov/pubmed/12925674
http://dx.doi.org/10.1084/jem.20030590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194177/
https://www.ncbi.nlm.nih.gov/pubmed/12925674
http://dx.doi.org/10.1084/jem.20030590

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