The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcɛRI-mediated Mast Cell Activation

The linker for activation of T cells (LAT) is an adaptor protein critical for FcɛRI-mediated mast cell activation. LAT is a substrate of the tyrosine kinases activated after TCR and FcɛRI engagement. After phosphorylation of the cytosolic domain of LAT, multiple signaling molecules such as phospholi...

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Detalles Bibliográficos
Autores principales: Saitoh, Shin-ichiroh, Odom, Sandra, Gomez, Gregorio, Sommers, Connie L., Young, Howard A., Rivera, Juan, Samelson, Lawrence E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194190/
https://www.ncbi.nlm.nih.gov/pubmed/12953098
http://dx.doi.org/10.1084/jem.20030574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194190/
https://www.ncbi.nlm.nih.gov/pubmed/12953098
http://dx.doi.org/10.1084/jem.20030574

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