The Proinflammatory Mediators C3a and C5a Are Essential for Liver Regeneration

Complement has been implicated in liver repair after toxic injury. Here, we demonstrate that complement components are essential for liver regeneration, and mediate their effect by interacting with key signaling networks that promote hepatocyte proliferation. C3- or C5-deficient mice exhibited high...

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Detalles Bibliográficos
Autores principales: Strey, Christoph W., Markiewski, Maciej, Mastellos, Dimitrios, Tudoran, Ruxandra, Spruce, Lynn A., Greenbaum, Linda E., Lambris, John D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194207/
https://www.ncbi.nlm.nih.gov/pubmed/12975457
http://dx.doi.org/10.1084/jem.20030374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194207/
https://www.ncbi.nlm.nih.gov/pubmed/12975457
http://dx.doi.org/10.1084/jem.20030374

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