Cargando…

The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4(+) T Cells

The quantitative adaptation of receptor thresholds allows cells to tailor their responses to changes in ambient ligand concentration in many biological systems. Such a cell-intrinsic calibration of T cell receptor (TCR) sensitivity could be involved in regulating responses to autoantigens, but this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Nevil J., Schwartz, Ronald H.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194218/ https://www.ncbi.nlm.nih.gov/pubmed/14530379 http://dx.doi.org/10.1084/jem.20030913

Ejemplares similares

The Impact of T Cell Intrinsic Antigen Adaptation on Peripheral Immune Tolerance
por: Singh, Nevil J, et al.
Publicado: (2006)

Thymic resident NKT cell subsets show differential requirements for CD28 co-stimulation during antigenic activation
por: Shissler, Susannah C., et al.
Publicado: (2020)

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction
por: Rouhani, Sherin J., et al.
Publicado: (2015)

Robust Iterative Stimulation with Self-Antigens Overcomes CD8(+) T Cell Tolerance to Self- and Tumor Antigens
por: Nelson, Christine E., et al.
Publicado: (2019)

GILT modulates CD4(+) T cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1
por: Rausch, Matthew P., et al.
Publicado: (2011)

Sensory Adaptation in Naive Peripheral CD4 T Cells
por: Smith, Katy, et al.
Publicado: (2001)

Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue Antigens
por: Heath, William R., et al.
Publicado: (1998)

The CD8α(+) Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens
por: Belz, Gabrielle T., et al.
Publicado: (2002)

Aire-Overexpressing Dendritic Cells Induce Peripheral CD4(+) T Cell Tolerance
por: Li, Dongbei, et al.
Publicado: (2015)

Neural adaptations to electrical stimulation strength training
por: Hortobágyi, Tibor, et al.
Publicado: (2011)

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
por: Obst, Reinhard, et al.
Publicado: (2005)

Acquisition of CD4-Dependence by CD4-Independent SIV Passaged in Human Peripheral Blood Mononuclear Cells
por: Iyengar, Sujatha, et al.
Publicado: (2012)

Modulation of CD4 antigen on macrophages and microglia in rat brain
Publicado: (1987)

IL-15 promotes self-renewal of progenitor exhausted CD8 T cells during persistent antigenic stimulation
por: Lee, Junghwa, et al.
Publicado: (2023)

The Reduction of Peripheral Blood CD4(+) T Cell Indicates Persistent Organ Failure in Acute Pancreatitis
por: Yang, Zhiyong, et al.
Publicado: (2015)

CD4(+) T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells
por: Adler, Adam J., et al.
Publicado: (1998)

Metabolic Adaptation of Human CD4(+) and CD8(+) T-Cells to T-Cell Receptor-Mediated Stimulation
por: Jones, Nicholas, et al.
Publicado: (2017)

Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
por: Takahashi, Takeshi, et al.
Publicado: (2000)

Diagnostic Value of CD25, CD69, and CD134 on Tuberculosis-Specific Antigen-Stimulated CD4+ T Cells for Tuberculous Pleurisy
por: Shi, Hanlu, et al.
Publicado: (2023)

Tolerance Induced by Antigen-Loaded PLG Nanoparticles Affects the Phenotype and Trafficking of Transgenic CD4(+) and CD8(+) T Cells
por: Neef, Tobias, et al.
Publicado: (2021)

Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8(+) T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation
por: Quenum, Akouavi Julite Irmine, et al.
Publicado: (2022)

CD45RC Isoforms Define Two Types of CD4 Memory T Cells, One of which Depends on Persisting Antigen
por: Bunce, Campbell, et al.
Publicado: (1997)

TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection
por: Maru, Saumya, et al.
Publicado: (2017)

Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4(+)FOXP3(+) T Regulatory Cells
por: Pohar, Jelka, et al.
Publicado: (2018)

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning
Publicado: (1995)

Brd4 Regulates the Homeostasis of CD8(+) T-Lymphocytes and Their Proliferation in Response to Antigen Stimulation
por: Peng, Zhilin, et al.
Publicado: (2021)

Immunological Memory Transferred with CD4 T Cells Specific for Tuberculosis Antigens Ag85B-TB10.4: Persisting Antigen Enhances Protection
por: Duffy, Darragh, et al.
Publicado: (2009)

Suboptimal Activation of Antigen-Specific CD4(+) Effector Cells Enables Persistence of M. tuberculosis In Vivo
por: Bold, Tyler D., et al.
Publicado: (2011)

CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells
por: Vacchio, Melanie S., et al.
Publicado: (2003)

IL‐12 and IL‐4 activate a CD39‐dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells
por: Noble, Alistair, et al.
Publicado: (2016)

The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
por: Lin, Hsi-Hsien, et al.
Publicado: (2005)

Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type
Publicado: (1995)

Functional Tolerance is Maintained Despite Proliferation of CD4 T Cells after Encounter with Tissue-derived Antigen
por: Ausubel, Lara J., et al.
Publicado: (2002)

The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation
Publicado: (1996)

Protection from Respiratory Virus Infections Can Be Mediated by Antigen-Specific Cd4(+) T Cells That Persist in the Lungs
por: Hogan, Robert J., et al.
Publicado: (2001)

Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd
por: Abrahamsen, Greger, et al.
Publicado: (2018)

CD4–CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation
por: Wang, Xiaojing, et al.
Publicado: (2012)

Antigen Specific Tolerance Inhibits Autoimmune Uveitis in Pre-sensitized Animals via Deletion and CD4(+)CD25(+) T-Regulatory Cells
por: Matta, Bharati, et al.
Publicado: (2009)

CD4 Depletion or CD40L Blockade Results in Antigen-Specific Tolerance in a Red Blood Cell Alloimmunization Model
por: Natarajan, Prabitha, et al.
Publicado: (2017)

Evaluation of Mycobacterium tuberculosis specific antigen-stimulated CD27(−)CD38(+)IFN-γ(+)CD4(+) T cells for discrimination of active tuberculosis
por: Fang, Yong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5o0brm2uun3lbe3vnnkkdj4ek2