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Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes
In type 1 diabetes, autoimmune T cells cause destruction of pancreatic β cells by largely unknown mechanism. Previous analyses have shown that β cell destruction is delayed but can occur in perforin-deficient nonobese diabetic (NOD) mice and that Fas-deficient NOD mice do not develop diabetes. Howev...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194221/ https://www.ncbi.nlm.nih.gov/pubmed/14530378 http://dx.doi.org/10.1084/jem.20030698 |