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Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes

In type 1 diabetes, autoimmune T cells cause destruction of pancreatic β cells by largely unknown mechanism. Previous analyses have shown that β cell destruction is delayed but can occur in perforin-deficient nonobese diabetic (NOD) mice and that Fas-deficient NOD mice do not develop diabetes. Howev...

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Detalles Bibliográficos
Autores principales:	Apostolou, Irina, Hao, Zhenyue, Rajewsky, Klaus, von Boehmer, Harald
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194221/ https://www.ncbi.nlm.nih.gov/pubmed/14530378 http://dx.doi.org/10.1084/jem.20030698

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