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Thrombospondin 1 Is an Autocrine Negative Regulator of Human Dendritic Cell Activation

Thrombospondin 1 (TSP) elicits potent antiinflammatory activities in vivo, as evidenced by persistent, multiorgan inflammation in TSP null mice. Herein, we report that DCs represent an abundant source of TSP at steady state and during activation. Human monocyte-derived immature dendritic cells (iDCs...

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Detalles Bibliográficos
Autores principales: Doyen, Virginie, Rubio, Manuel, Braun, Deborah, Nakajima, Toshiaru, Abe, Jun, Saito, Hirohisa, Delespesse, Guy, Sarfati, Marika
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194231/
https://www.ncbi.nlm.nih.gov/pubmed/14568985
http://dx.doi.org/10.1084/jem.20030705