Transforming Growth Factor (TGF)-β1–producing Regulatory T Cells Induce Smad-mediated Interleukin 10 Secretion That Facilitates Coordinated Immunoregulatory Activity and Amelioration of TGF-β1–mediated Fibrosis

Interleukin (IL)-10 and transforming growth factor (TGF)-β1 are suppressor cytokines that frequently occur together during a regulatory T cell response. Here we used a one gene doxycycline (Dox)-inducible plasmid encoding TGF-β1 to analyze this association and test its utility. In initial studies, w...

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Detalles Bibliográficos
Autores principales: Kitani, Atsushi, Fuss, Ivan, Nakamura, Kazuhiko, Kumaki, Fumiyuki, Usui, Takashi, Strober, Warren
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194234/
https://www.ncbi.nlm.nih.gov/pubmed/14557415
http://dx.doi.org/10.1084/jem.20030917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194234/
https://www.ncbi.nlm.nih.gov/pubmed/14557415
http://dx.doi.org/10.1084/jem.20030917

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