The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells

Systemic autoimmune disease is frequently characterized by the production of autoantibodies against widely expressed intracellular self-antigens, whereas B cell tolerance to ubiquitous and highly expressed extracellular antigens is strictly enforced. To test for differences in the B cell response to...

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Detalles Bibliográficos
Autores principales: Ferry, Helen, Jones, Margaret, Vaux, David J., Roberts, Ian S.D., Cornall, Richard J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194246/
https://www.ncbi.nlm.nih.gov/pubmed/14597740
http://dx.doi.org/10.1084/jem.20030279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194246/
https://www.ncbi.nlm.nih.gov/pubmed/14597740
http://dx.doi.org/10.1084/jem.20030279

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