Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic Switch

BACKGROUND: The complex interplay between B-cell lymphoma 2 (Bcl-2) family proteins constitutes a crucial checkpoint in apoptosis. Its detailed molecular mechanism remains controversial. Our former modeling studies have selected the ‘Direct Activation Model’ as a better explanation for experimental...

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Detalles Bibliográficos
Autores principales: Cui, Jun, Chen, Chun, Lu, Haizhu, Sun, Tingzhe, Shen, Pingping
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194625/
https://www.ncbi.nlm.nih.gov/pubmed/18213378
http://dx.doi.org/10.1371/journal.pone.0001469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194625/
https://www.ncbi.nlm.nih.gov/pubmed/18213378
http://dx.doi.org/10.1371/journal.pone.0001469

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