In vitro characterization and inhibition of the CXCR4/CXCL12 chemokine axis in human uveal melanoma cell lines

PURPOSE: The CXCR4/CXCL12 chemokine axis may play a critical role in guiding CXCR4+ circulating malignant cells to organ specific locations that actively secrete its ligand CXCL12 (SDF-1) such as bone, brain, liver, and lungs. We sought to characterize the presence of the CXCR4/CXCL12 axis in five u...

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Detalles Bibliográficos
Autores principales: Di Cesare, Sebastian, Marshall, Jean-Claude, Fernandes, Bruno F, Logan, Patrick, Antecka, Emilia, Filho, Vasco Bravo, Burnier, Miguel N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194662/
https://www.ncbi.nlm.nih.gov/pubmed/18001467
http://dx.doi.org/10.1186/1475-2867-7-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194662/
https://www.ncbi.nlm.nih.gov/pubmed/18001467
http://dx.doi.org/10.1186/1475-2867-7-17

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