Molecular dynamics simulation of human LOX-1 provides an explanation for the lack of OxLDL binding to the Trp150Ala mutant

BACKGROUND: Dimeric lectin-like oxidized low-density lipoprotein receptor-1 LOX-1 is the target receptor for oxidized low density lipoprotein in endothelial cells. In vivo assays revealed that in LOX-1 the basic spine arginine residues are important for binding, which is lost upon mutation of Trp150...

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Detalles Bibliográficos
Autores principales: Falconi, Mattia, Biocca, Silvia, Novelli, Giuseppe, Desideri, Alessandro
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194713/
https://www.ncbi.nlm.nih.gov/pubmed/17988382
http://dx.doi.org/10.1186/1472-6807-7-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194713/
https://www.ncbi.nlm.nih.gov/pubmed/17988382
http://dx.doi.org/10.1186/1472-6807-7-73

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