Ectopic Expression of AID in a Non-B Cell Line Triggers A∶T and G:C Point Mutations in Non-Replicating Episomal Vectors

Somatic hypermutation (SHM) of immunoglobulin genes is currently viewed as a two step process initiated by the deamination of deoxycytidine (C) to deoxyuridine (U), catalysed by the activation induced deaminase (AID). Phase 1 mutations arise from DNA replication across the uracil residue or the abas...

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Detalles Bibliográficos
Autores principales: Jovanic, Tihana, Roche, Benjamin, Attal-Bonnefoy, Géraldine, Leclercq, Olivier, Rougeon, François
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195452/
https://www.ncbi.nlm.nih.gov/pubmed/18213388
http://dx.doi.org/10.1371/journal.pone.0001480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195452/
https://www.ncbi.nlm.nih.gov/pubmed/18213388
http://dx.doi.org/10.1371/journal.pone.0001480

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