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Anergy and Cytokine-Mediated Suppression as Distinct Superantigen-Induced Tolerance Mechanisms in Vivo

Recombinant-activating gene 2 (RAG-2(−/−)) T cell receptor–transgenic mice repeatedly injected with the superantigen staphylococcal enterotoxin A entered a tolerant state in which splenic CD4(+) T cells produced little interleukin (IL)-2, interferon γ, or IL-4. This state resulted from a combination...

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Detalles Bibliográficos
Autores principales: Miller, Carla, Ragheb, Jack A., Schwartz, Ronald H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195559/
https://www.ncbi.nlm.nih.gov/pubmed/10429670