Measuring Recent Thymic Emigrants in Blood of Normal and HIV-1–Infected Individuals before and after Effective Therapy

The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to quantify the number of recent thymic emigrants in blood based on the detection of a major excisional DNA byproduct (termed α1 circle) of T cell receptor rearrangement. By studying 532 normal individuals, we found...

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Detalles Bibliográficos
Autores principales: Zhang, Linqi, Lewin, Sharon R., Markowitz, Martin, Lin, Hsi-Hsun, Skulsky, Eva, Karanicolas, Rose, He, Yuxian, Jin, Xia, Tuttleton, Sarah, Vesanen, Mika, Spiegel, Hans, Kost, Rhonda, van Lunzen, Jan, Stellbrink, Hans-Juergen, Wolinsky, Steven, Borkowsky, William, Palumbo, Paul, Kostrikis, Leondios G., Ho, David D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195623/
https://www.ncbi.nlm.nih.gov/pubmed/10477556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195623/
https://www.ncbi.nlm.nih.gov/pubmed/10477556

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