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Measuring Recent Thymic Emigrants in Blood of Normal and HIV-1–Infected Individuals before and after Effective Therapy
The role of the thymus in HIV-1 pathogenesis remains unclear. We developed an assay to quantify the number of recent thymic emigrants in blood based on the detection of a major excisional DNA byproduct (termed α1 circle) of T cell receptor rearrangement. By studying 532 normal individuals, we found...
Autores principales: | Zhang, Linqi, Lewin, Sharon R., Markowitz, Martin, Lin, Hsi-Hsun, Skulsky, Eva, Karanicolas, Rose, He, Yuxian, Jin, Xia, Tuttleton, Sarah, Vesanen, Mika, Spiegel, Hans, Kost, Rhonda, van Lunzen, Jan, Stellbrink, Hans-Juergen, Wolinsky, Steven, Borkowsky, William, Palumbo, Paul, Kostrikis, Leondios G., Ho, David D. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195623/ https://www.ncbi.nlm.nih.gov/pubmed/10477556 |
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