Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail

Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a T cell costimulation receptor that delivers inhibitory signals upon activation. Although the tyrosine-based motif ((165)YVKM) within its cytoplasmic tail has been shown to associate in vitro with Src homology 2 domain–containing tyrosine phosphatase (SH...

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Detalles Bibliográficos
Autores principales: Nakaseko, Chiaki, Miyatake, Shoichiro, Iida, Tomohiko, Hara, Satoru, Abe, Ryo, Ohno, Hiroshi, Saito, Takashi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195638/
https://www.ncbi.nlm.nih.gov/pubmed/10499915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195638/
https://www.ncbi.nlm.nih.gov/pubmed/10499915

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