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Receptor Avidity and Costimulation Specify the Intracellular Ca(2+) Signaling Pattern in Cd4(+)Cd8(+) Thymocytes
Thymocyte maturation is governed by antigen–T cell receptor (TCR) affinity and the extent of TCR aggregation. Signals provided by coactivating molecules such as CD4 and CD28 also influence the fate of immature thymocytes. The mechanism by which differences in antigen–TCR avidity encode unique matura...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195644/ https://www.ncbi.nlm.nih.gov/pubmed/10510084 |