Allelic Exclusion of the T Cell Receptor β Locus Requires the Sh2 Domain–Containing Leukocyte Protein (Slp)-76 Adaptor Protein

Signaling via the pre-T cell receptor (TCR) is required for the proliferative expansion and maturation of CD4(−)CD8(−) double-negative (DN) thymocytes into CD4(+)CD8(+) double-positive (DP) cells and for TCR-β allelic exclusion. The adaptor protein SH2 domain–containing leukocyte protein (SLP)-76 ha...

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Detalles Bibliográficos
Autores principales: Aifantis, Iannis, Pivniouk, Vadim I., Gärtner, Frank, Feinberg, Jacqueline, Swat, Wojciech, Alt, Frederick W., von Boehmer, Harald, Geha, Raif S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195661/
https://www.ncbi.nlm.nih.gov/pubmed/10523607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195661/
https://www.ncbi.nlm.nih.gov/pubmed/10523607

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