A Specific Role of Phosphatidylinositol 3–Kinase γ: A Regulation of Autonomic Ca(2)+ Oscillations in Cardiac Cells

Purinergic stimulation of cardiomyocytes turns on a Src family tyrosine kinase–dependent pathway that stimulates PLCγ and generates IP(3), a breakdown product of phosphatidylinositol 4,5–bisphosphate (PIP2). This signaling pathway closely regulates cardiac cell autonomic activity (i.e., spontaneous...

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Detalles Bibliográficos
Autores principales: Bony, Claire, Roche, Serge, Shuichi, Ueno, Sasaki, Takehiko, Crackower, Michael A., Penninger, Josef, Mano, Hiroyuki, Pucéat, Michel
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195768/
https://www.ncbi.nlm.nih.gov/pubmed/11266463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195768/
https://www.ncbi.nlm.nih.gov/pubmed/11266463

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