Protease-Activated Receptor 1 Mediates Thrombin-Dependent, Cell-Mediated Renal Inflammation in Crescentic Glomerulonephritis

Protease-activated receptor (PAR)-1 is a cellular receptor for thrombin that is activated after proteolytic cleavage. The contribution of PAR-1 to inflammatory cell–mediated renal injury was assessed in murine crescentic glomerulonephritis (GN). A pivotal role for thrombin in this model was demonstr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cunningham, Malcolm A., Rondeau, Eric, Chen, Xin, Coughlin, Shaun R., Holdsworth, Stephen R., Tipping, Peter G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195821/
https://www.ncbi.nlm.nih.gov/pubmed/10662791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195821/
https://www.ncbi.nlm.nih.gov/pubmed/10662791

Ejemplares similares