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Cd40 Ligand (Cd154) Triggers a Short-Term Cd4(+) T Cell Activation Response That Results in Secretion of Immunomodulatory Cytokines and Apoptosis
Signals generated through CD28–B7 and CD40 ligand (CD40L)–CD40 interactions have been shown to be crucial for the induction of long-term allograft survivability. We have recently demonstrated that humanized anti-CD40L (hu5C8) prevents rejection of mismatched renal allografts in primates. To investig...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195831/ https://www.ncbi.nlm.nih.gov/pubmed/10684857 |