Cd40 Ligand (Cd154) Triggers a Short-Term Cd4(+) T Cell Activation Response That Results in Secretion of Immunomodulatory Cytokines and Apoptosis

Signals generated through CD28–B7 and CD40 ligand (CD40L)–CD40 interactions have been shown to be crucial for the induction of long-term allograft survivability. We have recently demonstrated that humanized anti-CD40L (hu5C8) prevents rejection of mismatched renal allografts in primates. To investig...

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Detalles Bibliográficos
Autores principales: Blair, Patrick J., Riley, James L., Harlan, David M., Abe, Ryo, Tadaki, Douglas K., Hoffmann, Steven C., White, Leonard, Francomano, Tara, Perfetto, Stephen J., Kirk, Allan D., June, Carl H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195831/
https://www.ncbi.nlm.nih.gov/pubmed/10684857

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