Cargando…

Lck Domains Differentially Contribute to Pre–T Cell Receptor (Tcr)–And TCR-α/β–Regulated Developmental Transitions

Maturational changes at the CD4(−)CD8(−) double negative (DN) to CD4(+)CD8(+) double positive (DP) transition are dependent on signals generated via the pre–T cell receptor (TCR) and the nonreceptor protein tyrosine kinase p56(lck) (Lck). How Lck activities are stimulated or relayed after pre-TCR fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Kui, Longo, Nancy S., Wang, Xin, Hewitt, Judy A., Abraham, Kristin M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2000
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195836/ https://www.ncbi.nlm.nih.gov/pubmed/10684862

Ejemplares similares

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy
por: Bommhardt, Ursula, et al.
Publicado: (2019)

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling
por: Hartl, Frederike A., et al.
Publicado: (2021)

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor
por: Casas, Javier, et al.
Publicado: (2014)

TCR Triggering Induces the Formation of Lck–RACK1–Actinin-1 Multiprotein Network Affecting Lck Redistribution
por: Ballek, Ondřej, et al.
Publicado: (2016)

Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement
por: Filipp, Dominik, et al.
Publicado: (2012)

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
por: Schultz, Annika, et al.
Publicado: (2022)

Roles of the Src Tyrosine Kinases Lck and Fyn in Regulating γδTCR Signal Strength
por: Laird, Renee M., et al.
Publicado: (2010)

Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells
por: Galetto, Román, et al.
Publicado: (2014)

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity
por: Azzam, Hala S., et al.
Publicado: (1998)

A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization
por: Zhou, Bo, et al.
Publicado: (2011)

Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells
por: Lipp, Anna M., et al.
Publicado: (2014)

The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37
por: Kowallik, Sarah, et al.
Publicado: (2020)

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit
Publicado: (1995)

NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data
por: Montemurro, Alessandro, et al.
Publicado: (2021)

ATM Influences the Efficiency of TCRβ Rearrangement, Subsequent TCRβ-Dependent T Cell Development, and Generation of the Pre-Selection TCRβ CDR3 Repertoire
por: Hathcock, Karen S., et al.
Publicado: (2013)

Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System
por: Yokosuka, Tadashi, et al.
Publicado: (2002)

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros
por: Winandy, Susan, et al.
Publicado: (1999)

Mathematical modeling identifies Lck as a potential mediator for PD-1 induced inhibition of early TCR signaling
por: Arulraj, Theinmozhi, et al.
Publicado: (2018)

Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection
por: Kästle, Matthias, et al.
Publicado: (2022)

HIV-1 Nef Employs Two Distinct Mechanisms to Modulate Lck Subcellular Localization and TCR Induced Actin Remodeling
por: Haller, Claudia, et al.
Publicado: (2007)

Identifying T Cell Receptors from High-Throughput Sequencing: Dealing with Promiscuity in TCRα and TCRβ Pairing
por: Lee, Edward S., et al.
Publicado: (2017)

A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires
por: Tanno, Hidetaka, et al.
Publicado: (2020)

A set point in the selection of the αβTCR T cell repertoire imposed by pre-TCR signaling strength
por: Bovolenta, Elena R., et al.
Publicado: (2022)

γδTCR immunoglobulin constant region domain exchange in human αβTCRs improves TCR pairing without altering TCR gene-modified T cell function
por: Tao, Changli, et al.
Publicado: (2017)

Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
por: Kuball, Jürgen, et al.
Publicado: (2009)

Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function
por: Degirmencay, Abdullah, et al.
Publicado: (2023)

The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling
por: Hagenbeek, Thijs J., et al.
Publicado: (2004)

An Endoplasmic Reticulum Retention Function for the Cytoplasmic Tail of the Human Pre–T Cell Receptor (Tcr) α Chain: Potential Role in the Regulation of Cell Surface Pre-Tcr Expression Levels
por: Carrasco, Yolanda R., et al.
Publicado: (2001)

A discrete chromatin loop in the murine Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires
por: Chen, Liang, et al.
Publicado: (2015)

TCR-Induced Tyrosine Phosphorylation at Tyr270 of SUMO Protease SENP1 by Lck Modulates SENP1 Enzyme Activity and Specificity
por: Li, Yun-Yi, et al.
Publicado: (2022)

TCR–pMHC bond conformation controls TCR ligand discrimination
por: Sasmal, Dibyendu K., et al.
Publicado: (2019)

TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential
por: Poorebrahim, Mansour, et al.
Publicado: (2021)

epiTCR: a highly sensitive predictor for TCR–peptide binding
por: Pham, My-Diem Nguyen, et al.
Publicado: (2023)

The timing of TCRα expression critically influences T cell development and selection
por: Baldwin, Troy A., et al.
Publicado: (2005)

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains
Publicado: (1994)

TCR chain gangs
por: Van Epps, Heather L.
Publicado: (2005)

Autoimmune TCR structure
por: LeBrasseur, Nicole
Publicado: (2005)

Far from the TCR
por: Bätz, M
Publicado: (2004)

On the Control of TCR Phosphorylation
por: Fernandes, Ricardo A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_de9crgmcbgjbt3osalrvaabe0a