A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity: Aberrant Development and Enhanced Function of B Lymphocytes in Ship(−/)− Mice

In this report, we demonstrate that the Src homology 2 domain–containing inositol-5-phosphatase (SHIP) plays a critical role in regulating both B cell development and responsiveness to antigen stimulation. SHIP(−/−) mice exhibit a transplantable alteration in B lymphoid development that results in r...

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Detalles Bibliográficos
Autores principales: Helgason, Cheryl D., Kalberer, Christian P., Damen, Jacqueline E., Chappel, Suzanne M., Pineault, Nicolas, Krystal, Gerald, Humphries, R. Keith
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195854/
https://www.ncbi.nlm.nih.gov/pubmed/10704460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195854/
https://www.ncbi.nlm.nih.gov/pubmed/10704460

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