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A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity: Aberrant Development and Enhanced Function of B Lymphocytes in Ship(−/)− Mice
In this report, we demonstrate that the Src homology 2 domain–containing inositol-5-phosphatase (SHIP) plays a critical role in regulating both B cell development and responsiveness to antigen stimulation. SHIP(−/−) mice exhibit a transplantable alteration in B lymphoid development that results in r...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2000
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195854/ https://www.ncbi.nlm.nih.gov/pubmed/10704460 |