The Long Isoform of Terminal Deoxynucleotidyl Transferase Enters the Nucleus And, Rather than Catalyzing Nontemplated Nucleotide Addition, Modulates the Catalytic Activity of the Short Isoform

During variable/diversity/joining (V[D]J) recombination, the enzyme terminal deoxynucleotidyl transferase (Tdt) adds random nucleotides at the junctions of the rearranging gene segments, increasing diversity of the antibody (Ab) and T cell receptor repertoires. Two splice variants of Tdt have been d...

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Detalles Bibliográficos
Autores principales: Benedict, Cindy L., Gilfillan, Susan, Kearney, John F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195880/
https://www.ncbi.nlm.nih.gov/pubmed/11136823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195880/
https://www.ncbi.nlm.nih.gov/pubmed/11136823

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