Loss of Precursor B Cell Expansion but Not Allelic Exclusion in VpreB1/VpreB2 Double-Deficient Mice

The pre-B cell receptor consists of immunoglobulin (Ig) μ heavy chains and surrogate light chain, i.e., the VpreB and λ5 proteins. To analyze the role of the two VpreB proteins, mice lacking the VpreB1 and VpreB2 genes were generated. VpreB1 (−) (/)−VpreB2 (−) (/)− mice were impaired in their B cell...

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Detalles Bibliográficos
Autores principales: Mundt, Cornelia, Licence, Steve, Shimizu, Takeyuki, Melchers, Fritz, Mårtensson, Inga-Lill
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195903/
https://www.ncbi.nlm.nih.gov/pubmed/11181696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195903/
https://www.ncbi.nlm.nih.gov/pubmed/11181696

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