Eliciting the Low-Activity Aldehyde Dehydrogenase Asian Phenotype by an Antisense Mechanism Results in an Aversion to Ethanol

A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2–2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol...

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Detalles Bibliográficos
Autores principales: Garver, Eric, Tu, Guang-chou, Cao, Qing-Na, Aini, Maria, Zhou, Feng, Israel, Yedy
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195938/
https://www.ncbi.nlm.nih.gov/pubmed/11535626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195938/
https://www.ncbi.nlm.nih.gov/pubmed/11535626

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