The Biological Activity of Natural and Mutant Ptα Alleles

β selection is a major checkpoint in early thymocyte differentiation, mediated by successful expression of the pre-T cell receptor (TCR) comprising the TCRβ chain, CD3 proteins, and a surrogate TCRα chain, pTα. The mechanism of action of the pre-TCR is unresolved. In humans and mice, the pTα gene en...

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Detalles Bibliográficos
Autores principales: Gibbons, Deena, Douglas, Nataki C., Barber, Domingo F., Liu, Qiang, Sullo, Renee, Geng, Liping, Fehling, Hans-Joerg, von Boehmer, Harald, Hayday, Adrian C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195948/
https://www.ncbi.nlm.nih.gov/pubmed/11535637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195948/
https://www.ncbi.nlm.nih.gov/pubmed/11535637

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